Department of Anatomy

Faculty of Medicine

Research


Dr. Devika Gunasinghe
Research Interest
My field of study is invasion and metastasis of cancer. I mainly focus on the process of epithelial to mesenchymal transition during cancer metastasis
 
Oral and poster presentation with abstracts 2010
  • D. Gunasinghe, T. Blick, J. Allison, M. Waltham, H. J. Hugo, E. W. Thompson. Diverse effects of epidermal growth factor in the MDA-MB-468 human breast cancer model. International Cancer Conference, Lorne, Victoria, Australia, 2010
Oral and poster presentations(with abstracts)2011
  • D. Gunasinghe, T. Blick, J. Allison, M. Waltham, H. J. Hugo, E. W. Thompson. Epidermal growth factor directed reduction of cell proliferation in MDA-MB-468 cells is cell density dependent and EMT associated. International Cancer Conference, Lorne, Victoria, Australia, 2011
  • D. Gunasinghe, T. Blick, A. Tachtsidis, M. Waltham, H. J. Hugo, E. W. Thompson. Modulation of epithelial to mesenchymal transition by manipulation of cell adhesion molecule E-cadherin. Proceedings of the Annual Research Sessions, St. Vincent’s cluster, University of Melbourne, Australia, 2011
  •  A. Tachtsidis,T. Blick, D. Gunasinghe, P. F. M. Choong, M. Waltham, A. Dobrovic, E. W. Thompson. Epithelial mesenchymal plasticity in human breast cancer xenograft models of circulating and disseminated tumour cells. International Epithelial and Mesenchymal Transition Meeting, Biopolis, Singapore, 2011
  • A. Tachtsidis,T. Blick, D. Gunasinghe, P. F. M. Choong, M. Waltham, A. Dobrovic, E. W. Thompson. Epithelial mesenchymal plasticity in human breast cancer xenograft models of circulating and disseminated tumour cells. International Epithelial and Mesenchymal Transition Meeting, Biopolis, Singapore, 2011
  • A. Tachtsidis,T. Blick, D. Gunasinghe, P. F. M. Choong, M. Waltham, A. Dobrovic, E. W. Thompson. Epithelial mesenchymal plasticity in human breast cancer xenograft models of circulating and disseminated tumour cells. International Epithelial and Mesenchymal Transition Meeting, Biopolis, Singapore, 2011
  • A. Tachtsidis,T. Blick, D. Gunasinghe, P. F. M. Choong, M. Waltham, A. Dobrovic, E. W. Thompson. Studying circulating and disseminated tumour cells in human breast cancer xenograft models. International Symposium on Minimal Residual Cancer, Osaka, Japan, 2011
  • A. Tachtsidis,T. Blick, D. Gunasinghe, P. F. M. Choong, M. Waltham, A. Dobrovic, E. W. Thompson. Studying circulating and disseminated tumour cells in human breast cancer xenograft models. International Symposium on Minimal Residual Cancer, Osaka, Japan, 2011
  • D. Gunasinghe, A. Tachtsidis, T. E. Soo, C. Pinto, E. Widodo, Rhiannon Coulson, T. Blick, D. Huang, H. Hugo, E. Tomaskovic-Crook, B. van Denderen, M. Waltham, E. W. Thompson. Epihelial-mesenchymal plasticity and breast cancer metastasis – Insights from human breast cancer cell lines. International Conference on New Concepts in Cancer Metastasis, Lisbon, Portugal, 2011
 
Oral and poster presentations(with abstracts)2012
  • A. Tachtsidis, T. Blick,D. Gunasinghe, M. Waltham, A. Dobrovic, E. W. Thompson. Molecular analysis of circulating (CTC) and disseminated tumour cells (DTC) in human breast cancer xenograft models. International Conference on Advances in Circulating Tumour Cells, Athens, Greece, 2012
  • A. Tachtsidis, D. Gunasinghe, T. Blick, D. Huang, E. L. de Sousa, A. Dobrovic,M. Waltham, E. W. Thompson. Epithelial mesenchymal plasticity in xenograft models of circulating and disseminated tumour cells from human breast cancer. Proceedings of American Association for Cancer Research 103rd Annual Meeting, Chicago, USA, 2012.
    Cancer Research – Vol 72, Issue 8, 2012
Journal Publication 2012
 
Journal Publication 2013
  • Hugo, H.J, Pereira, L., Suryadinata, R., Drabsch, Y., Gonda, T.J., Gunasinghe, N.P.A.D., Pinto, C., Soo, E.T.L., vanDenderen, B., Hill, P., Ramsay, R.G., Sarcevic, B., Newgreen, D.F., Thompson. E.W., Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to mesenchymal transition of breast cancer cells. Breast Cancer Research, 2013 Nov. 15(6): R113.   
 
Prof. S.B. Adikari
Research interests
  • Osteoarthritis and articular cartilage damage.       
  • Characterization of the Immune Response to Leishmaniasis in the Sri Lankan population. 
    Species identification, pathophysiology, immune response and transmission of rickettsial infections in the central province of Sri Lanka.
 
Oral and Poster Presentation( with abstract) 2010
  • D.N Atapattu, WMDR Iddawela, SB Adikari, RPVJ Rajapakse, D Karunarathna, KA Wijewardena, CS Dassanayake, MATU Mallawarachchi, NLS Wijesundara and DRLN Bandara. Cutaneous Leishmaniasis in Sri Lanka: The Clinical Profile. Oral presentation. Peradeniya University Research Sessions (PURSE)-2010, Peradeniya, Sri Lanka, December 2010, Volume 15 – Part I, Page 89-91
  • HA Amaratunga, M Chandrasekara, SB Adikari, EGJ. Gamage and HJ. Suraweera. A Comparison Between Direct Visual and Histopathological Grading Systems of Articular Cartilage Lesions in Osteoarthritic Knees. Poster presentation. Peradeniya University Research Sessions (PURSE)-2010, Peradeniya, Sri Lanka, December 2010, Volume 15 – Part I, Page 238-239.
  • HA AmaratungaM Chandrasekara, SB Adikari and HJ Suraweera. The Effect of Age, BMI and Osteoarthritis on the alignment of the Knee Joint in Females. Oral presentation. Peradeniya University Research Sessions (PURSE)-2010, Peradeniya, Sri Lanka, December 2010, Volume 15 – Part I, Page 151-153.
  • H.A. Amaratunga, Malkanthi Chandrasekara, S.B. Adikari and H.J. Suraweera (2010). The effect of age, BMI and osteoarthritis on the alignment of the knee joint in females; Peradeniya University Research Sessions, book of proceedings, volume 15 part 1; page 151-53
  • H.A. Amaratunga, Malkanthi Chandrasekara, S.B. Adikari, E.G.J.Gamage and H.J. Suraweera (2010). A comparison between direct visual and histopathological grading systems of articular cartilage lesions in osteoarthritic knees; PURSE book of proceedings, volume 15 part 1; page 238-40
Oral and Poster Presentation( with abstract) 2011
  • Peradeniya University Research Sessions (PURSE)-2011, Peradeniya, Sri Lanka, November 2011, Volume 16, Page 101.  KGAD Weerakoon, RPVJ Rajapakse, SB Adikari, SC Medagedara, DM Nanayakkara, S Ranasingha and SAM Kularatne.
  • Serodiagnosis of Clinically Suspected Cases of Rickettsial Infections Presented at Teaching Hospital, Peradeniya. Oral presentation. Peradeniya University Research Sessions (PURSE)-2011, Peradeniya, Sri Lanka, November 2011, Volume 16, Page 102.
  • KGAD Weerakoon, RPVJ Rajapakse, SB Adikari, SC Medagedara, DM Nanayakkara, S Ranasingha and SAM Kularatne. Clinical and Laboratory Features of Spotted Fever Rickettsiosis in Patients Presented to Teaching Hospital, Peradeniya. Oral presentation. Peradeniya University Research Sessions (PURSE)-2011, Peradeniya, Sri Lanka, November 2011, Volume 16, Page 100
  • HA Amaratunga, SPM Peiris, SB Adikari, M Chandrasekara and HJ Suraweera. A Priliminary Study on Characteristics of Patients with Primary Osteoarthritis of the Knee Undergoing Joint Replacement. Oral presentation. Peradeniya University Research Sessions (PURSE)-2011, Peradeniya, Sri Lanka, November 2011, Volume 16, Page 76
  • Weerakoon KGAD, Rajapkse RPVJ, Adikari SB, Medegedara SC, Nanayakkara DM, Ranasinghe S, Kularatne SAM, 2011, Clinical and laboratory features of spotted fever Rickettsioses in patients presented to Teaching Hospital Peradeniya.
  • KGAD Weerakoon, RPVJ Rajapakse, SB Adikari, SC Medagedara, DM Nanayakkara, S Ranasingha and SAM Kularatne. Burden of Rickettsioses in the Central Province of Sri Lanka. Oral presentation. Rajarata University Research Sessions-2011, Mihintale, Sri Lanka, November 2011, Page 126-129.
Oral and Poster Presentation( with abstract) 2012    
  • Ekanayake PMNS, Adikari SB, Ranaraja SK, Jayasundara DMCS, Jayarathne YRI. Anatomical variations of the human vermiform appendix in female patients who underwent gynaecological surgeries: A preliminary study. Anual academic sessions of the Kandy Society of Medicine. Feb 2012, volume 34, page 50.
Journal Publications 2013 - International
  • Gustafsson, R.K., Engdahl, E.E., Hammarfjord, O., Adikari, S.B., Lourda, M., Klingstrom, J., Sevensson, M., Fogdell- Hahn. A.,Human Herpes virus 6A partially suppresses functional properties of DC without viral replication. PLoS one, 2013. 8(3): e58122.
 
Dr. H.M.A. Sominanda
Research Interests
  • Field of Research Interests - Neurology and Neuroimmunology
Oral and Poster Presentation( with abstract) 2010
  • Sominanda A,  Kieseier BC, et al. Inhibition of endogenous interferon beta by neutralizing antibodies against recombinant interferon beta. Archives of Neurology. 2010 Sep;67(9):1095-101
  • Steinberg A, Sjöstrand C, Sominanda A, Fogdell-Hahn A, Nilsson Remahl AI. Interleukin-2 gene expression in different phases of episodic cluster headache. Acta Neurol Scand. 2010Sep 29
  • A Sominananda, BC KieseierInteractionof anti INF beta antibodies and macrophages PURSE 2010
Journal Publication 2010
Journal Publication 2011
Journal Publication 2012
 
Dr. Deepthi Nanayakkara
Research interests 
  • Breast imaging
  • Snake venom toxicology
Oral and Poster Presentation( with abstract) 2010 
  • V P Gunaratne, A G G Wijeratne, S B P Athauda, R M P Rathnayake, S Ranasinghe, D P Nanayakkara, Histopathological effects of crude venom and purified phospholipase A2 from Russell’s viper (Vipera russelli russelli) in mice: A preliminary study, Proceedings of Peradeniya University research sessions, 2010,15: 1, 75-76
 
Sachithra D. Samarawickrame
Research Interests
My research focuses on identifying the biomechanical and physiological risk factors associated with lower-extremity injuries in athletes. Specifically, I am interested in muscle and tendon adaptation in response to fatigue and eccentric overloading. I am currently using barefoot running as a model to study these adaptations.  My research will ultimately contribute to the development of effective strategies that reduce the prevalence and severity of injuries related to myotendinous injuries related to sports participation
Oral and Poster Presentation( with abstract) 2011
  • Sachithra Samarawickrame, Rami Hashish, George Salem.  Kinematic and kinetic differences between shod and barefoot running.  American Society of Biomechanics,  August 2011. Abstract
  • Rami Hashish, Sachithra Samarawickrame, George Salem.  Ground reaction forces in barefoot running before and after exertion.  American Society of Biomechanics,  August 2011. Abstract
  • Man-Ying Wang, Shin-Yuan Yu, Rami Hashish, Sachithra Samarawickrame, Michelle Haines, Lauren Mulwitz, Leslie Kazadi, Gail Greendale, George Salem. Biomechanics demands of therapeutic hatha yoga poses in older adults: modified chair and downward facing dog.  American Society of Biomechanics,  August 2011. Abstract
  • Sean S.Y. Yu, Man-Ying Wang, Lauren Mulwitz, Michelle Haines, Sachithra Samarawickrame, Rami Hashish, Leslie Kazadi, Gail Greendale, George Salem. Conventional wisdom regarding yoga pose modification may not benefit healthy older adults: examining the modified tree pose.  American Society of Biomechanics,  August 2011. Abstract
  • Samarawickrame S, Wang M-Y, Hashish R, Yu S-Y, Haines M, Mulwitz L, Greendale G, Salem G. Biomechanical Characteristics of the Modified Downward Facing Dog Yoga Pose in Healthy Older Adults. Med Sci Sports Exerc.  June 2011;43(5): S652. Abstract
  • Hashish R, Samarawickrame S, Wang M-Y, Yu S-Y, Tsai LC, Salem G. The Influence Of Different Marker Sets On Lower Extremity Dynamics During Walking. Med Sci Sports Exerc. June 2011;43(5): S639. Abstract
  • Yu S-Y, Wang M-Y, Haines M, Mulwitz L, Hashish R, Samarawickrame S, Kazadi L, Greendale G, Salem G. Lower-extremity Joint Kinematics in Older Adults Performing the Warrior I Pose of Hatha Yoga. Med Sci Sports Exerc.  June 2011;43(5): S652. Abstract
  • R. Hashish, S. Samarawickrame, MY Wang, SY Yu, G. Salem.  Normalized Knee Extensor Strength and TUG Performance in Community Dwelling Older Adults. Physical Therapy  June 2011. Abstract
Oral and Poster Presentation( with abstract) 2012 
  • Sachithra Samarawickrame, Rami Hashish, Kush Gaur, George Salem.  Exertion Modulates Ankle Joint Co-Activation During Novel Barefoot and Post-Transition Barefoot Running Conditions.  American Society of Biomechanics, 2012. Abstract
  • Rami Hashish, Sachithra Samarawickrame, Kush Gaur, George Salem.  Mechanical Demand Distribution During Shod and Novice Barefoot Running.  American Society of Biomechanics, 2012. Abstract
  • Sachithra Samarawickrame, Rami Hashish, Kush Gaur, George Salem.  Adaptive Changes in Plantar-flexor Performance Following a Transition from Shod to Barefoot Running.  American College of Sports Medicine, 2012. Abstract
  • Rami Hashish, Sachithra Samarawickrame, Kush Gaur, George Salem.  Adaptation of Contact Dynamics Following an Eight-Week Transition from Shod to Barefoot Running.  American College of Sports Medicine, 2012.  Abstract
  • Man-Ying Wang, Shin-Yuan Yu, Michelle Haines, Rami Hashish, Sachithra Samarawickrame, Gail Greendale, George Salem.  Can Yoga Improve Balance Performance in Older Adults?  American College Sports Medicine, 2012. Abstract
  • Rami Hashish, Sachithra Samarawickrame, Christopher Powers, George Salem.  Foot Contact Patterns and Joint Demands in Novice Barefoot Runners Before and After Exertion.  Combined Sections Meeting,  February 2012.
Journal Publication 2012
Journal Publications 2013 - International
  • Wang, M.Y., Sean S.Y. Yu, Hashish, R., Samarawickrame, S.D., Kazadi, L., Greendale, G.A., Salem. G.J., The biomechanical demands of standing yoga poses in seniors: The Yoga empowers seniors study (YESS). BMC Complementary and Alternative Medicine 2013. 13:8
 
Dr. Himani Amaratunga
Research Interests
  • Osteoarthritis: risk factors and prognostic factorsCartilage structure, Knee joint mechanics.
    Breast Cancer risk factors, Benign breast disease.
Oral and Poster Presentation( with abstract) 2010
  • H.A. Amaratunga, Malkanthi Chandrasekara, S.B. Adikari and H.J. Suraweera (2010). The effect of age, BMI and osteoarthritis on the alignment of the knee joint in females; Peradeniya University Research Sessions, book of proceedings, volume 15 part 1; page 151-53
  • H.A. Amaratunga, Malkanthi Chandrasekara, S.B. Adikari, E.G.J.Gamage and H.J. Suraweera (2010). A comparison between direct visual and histopathological grading systems of articular cartilage lesions in osteoarthritic knees; PURSE book of proceedings, volume 15 part 1; page 238-40
  • GKS De Silva, H Perera, S Karunarathne, RS Jayamuni, W Soysa, MR Illeperuma, DRKK Dissanayaka, CS Dunuwilla, A Hewage, H.A. Amaratunga, SPM Peiris. Guidelines on management of breast cancer: has it reached the end user. 32nd Annual Academic Sessions of the Kandy Society of Medicine 2010, Book of Abstracts;70
  • Kanishka de Silva, H.A. Amaratunga, S.P.M. Peiris, Anoma de Silva, D.R.K.C Dissanayake. Age specific frequency of common breast conditions among patients presenting with breast lumps.32nd Annual Academic Sessions of the Kandy Society of Medicine 2010, Book of Abstracts;95
  • Kanishka de Silva, H.A. Amaratunga, S.P.M. Peiris, Anoma de Silva.An audit of fibroadenoma cases. 32nd Annual Academic Sessions of the Kandy Society of Medicine 2010, Book of Abstracts;96
  • Kanishka de Silva, H.A. Amaratunga, S.P.M. Peiris, Anoma de Silva.Sensitivity and specificity of triple assessment in detecting breast cancer at the Oncosurgical Unit Kandy. 32nd Annual Academic Sessions of the Kandy Society of Medicine 2010, Book of Abstracts;97
Oral and Poster Presentation( with abstract) 2011
  • H.A. Amaratunga, S.P.M. Peiris, S.B. Adikari, Malkanthi Chandrasekara and H.J. Suraweera (2011) A priliminary study of the characteristics of patients with primary osteoarthritis of the knee undergoing joint replacement. Peradeniya University Research Sessions, book of proceedings, volume 16; 76
Oral and Poster Presentation( with abstract) 2012   
  • S.P.M. Peiris, H.A. Amaratunga, R.J.K. Seneviratne (2012). Successful anal sphincter repair without colostomy: 34th annual academic sessions of the Kandy Society of Medicine 2012, proceedings and abstracts: 71
  • S.P.M. Peiris, S. Ratnayake, B. Dissanayake, H.A. Amaratunga, R.J.K. Seneviratne (2012). A case of obstructive jaundice caused by a plant bezor in the common bile duct: 34th annual academic sessions of the Kandy Society of Medicine 2012, proceedings and abstracts: 72
 
Dr.Jayampathy Dissanayake
Research Interests
  • Studies on X chromatine/chromosome 
  • Studies on Somatotype 
  • Dermatoglyphics
  • Dysmorphology and genetic counseling
Oral and Poster Presentation( with abstract) 2011
  • Weerasinghe, A.M., Wijethilake, B.H.W.M.G.T., Ratnayake, A., Suraweera, H.J., Dissanayake, J.K. (2011) A preliminary study of distribution of somatotypes among SriLankan male elite runners. Proceedings of the Peradeniya University Research Sessions, 16:87
  • Wijethilake, B.H.W.M.G.T., Rajapaksha,C.,  Dissanayake, J.K. (2011) Study of cytotoxic and genotoxic effects of seven water sources in Sri Lanka. Proceedings of the Peradeniya University Research Sessions, 16:135
  • Ekanayake, P.M.N.S., Amiyangoda, C.K.G., Dissanayake, J.K.(2011)Turners syndrome: A case report  Proceedings of the Peradeniya University Research Sessions, 16:231 Poster
Journal Publication 2011
 
Dr. S.M.K. Gamage
Research Interests
  • Neuroimmunology
  • Neonatology
Oral and Poster Presentation( with abstract) 2010
  • Fernando D., Gamage S., et al. Is the weight of the baby sufficient to break the umbilical cord?. Proceedings of the Peradeniya University Research Sessions,Sri Lanka. Vol 15 (2010). P 130-132.
  • Is Knowledge on Legally Accepted age limits adequate among school children in Kandy Zone?Poster presentation at the 32nd Annual Academic Sessions of Kandy Society of Medicine (KSM) 2010.
Oral and Poster Presentation( with abstract) 2011
  • Fernando D., Weerakkody IR., Gamage SMK., et al. Relationship between gestational age and  anthropimetric parameters of neonates – A preliminary study.  Abstract Book of 9th Annual academic Sessions of College of Forensic Pathologists Sri Lanka. P 17.
Journal Publication 2011
  • Fernando D., Weerakkody IR., Gamage SMK., et al. Relationship between gestational age and  anthropimetric parameters of neonates – A preliminary study.  Medico Legal Journal of Sri Lanka. Vol. 1 (2011). P 14-19.