Prof. N.S. Kalupahana
Professor in Human Nutrition
 
Book Chapters
  1. Kalupahana NS, Moustaid-Moussa N, Voy BH, Kim JH, Bassett D, Bray MS, Lightfoot TJ. The Regulation of Physical Activity by Genetic Mechanisms: Is There a Drive to be Active? In: Genetic and Molecular Aspects of Sports Performance. Edited by Bouchard C, Hoffman E: Wiley-Blackwell; 2011: 283-293 [link]

  2. Bray MS, Fulton JE, Kalupahana NS, Lightfoot TJ. Genetic Epidemiology, Physical Activity and Inactivity. In: Genetic and Molecular Aspects of Sport Performance. Edited by Bouchard C, Hoffman E: Wiley-Blackwell; 2011: 81-89 [link]

  3. Siriwardhana N, Kalupahana NS and Moustaid-Moussa N. Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In Handbook of Marine Medicinal Food: Applications and Implications (2nd Ed.) Edited by Se-Kwon Kim: Elsevier; 2012 [Pubmed]

  4. Kalupahana NS, Jayalath T, Wang S and Moustaid-Moussa N. Regulation and metabolic effects of white adipose tissue SCD expression. In: Stearoyl Coenzyme-A Desaturase Genes in Lipid Metabolism. Edited by James M. Ntambi: Springer; 2013: 49-60 [link]

  5. Kalupahana NS, Wang S, Rahman S and Moustaid-Moussa N. Function and regulation of macrophage SCD in metabolic disorders. In: Stearoyl Coenzyme-A Desaturase Genes in Lipid Metabolism. Edited by James M. Ntambi: Springer; 2013:61-71 [link]
Publications in Peer-Reviewed Journals
  1. Kalupahana NS, Weerasinghe VS, Dangahadeniya U, Senanayake N. Abnormal parameters of magnetically evoked motor evoked potentials in patients with cervical spondylotic myelopathy. Spine Journal 2008; 8(4):645-9

  2. Wortman P, Miyazaki Y, Kalupahana NS, Kim S, Hansen-Petrik M, Saxton AM, Claycombe KJ, Voy BH, Whelan J and Moustaid-Moussa N. n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes. Nutrition & Metabolism 2009; 6:5

  3. Kalupahana NS, Claycombe K, Newman SJ, Stewart T, Siriwardhana N, Matthan N, Lichtenstein A and Moustaid-Moussa N. Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. Journal of Nutrition 2010; 140(11):1915-22

  4. Kalupahana NS, Voy BH, Saxton A and Moustaid-Moussa N. Energy-restricted high-fat diets only partially improve markers of systemic and adipose tissue inflammation. Obesity (Silver Spring) 2011; 19(2):245-54

  5. Kalupahana NS, Claycombe K and Moustaid-Moussa N. Omega-3 fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Advances in Nutrition 2011; 2: 304-316

  6. Kalupahana NS and Moustaid-Moussa N. Overview to Symposium “Systems Genetics in Nutrition and Obesity Research”. Journal of Nutrition 2011; 141(3):512-4

  7. Kalupahana NS, Moustaid-Moussa N. Genetics, Physical Activity and Chronic Diseases: an Intricate Relationship. Sri Lanka Medical Journal, 2011; 20(1):1-15

  8. Kalupahana NS and Moustaid-Moussa N. The adipose tissue renin-angiotensin system and metabolic disorders: a review of molecular mechanisms. Critical Reviews in Biochemistry and Molecular Biology, 2012;47(4):379-390

  9. Kalupahana NS, Massiera F, Quignard-Boulange A, Ailhaud G, Voy BH, Wasserman DH and Moustaid-Moussa N. Overproduction of angiotensinogen from adipose tissue induces adipose tissue inflammation, glucose intolerance and insulin resistance. Obesity (Silver Spring), 2012 Jan;20(1):48-56.

  10. Kalupahana NS, Moustaid-Moussa N and Claycombe K. Immunity as a link between obesity and insulin resistance. Molecular Aspects of Medicine, 2012 Feb;33(1):26-34.

  11. Kalupahana NS, Moustaid-Moussa N. The renin-angiotensin system: a link between obesity, inflammation and insulin resistance. Obesity Reviews, 2012 Feb;13(2):136- 49.

  12. Siriwardhana N, Kalupahana NS, Fletcher S, Xin W, Claycombe KJ, Quignard- Boulange A, Zhao L, Saxton AM, Moustaid-Moussa N. n-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines in part via NF-κB-dependent mechanisms. Journal of Nutritional Biochemistry, 2012; 23(12):1661-7

  13. Moustaid-Moussa N, Costello CA, Greer BP, Fitzhugh EC,  Spence ML, Muenchen RA and Kalupahana NS. Predictors of body mass index in female parents whose children participate in a competitive, creative, problem-solving program. Journal of Food and Nutrition Research, 2012; 56

  14. Shi LZ, Kalupahana NS, Turnis ME, Neale G, Hock H, Vignali DA, Chi H. Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells. Proc Natl Acad Sci USA. 2013; 110(34):E3198-205

  15. Fletcher SJ, Kalupahana NS, Bejnood M, Kim JH, Saxton AM, Wasserman D, De Taeye B, Voy BH, Quignard-Boulange A and Moustaid-Moussa N. Transgenic mice overexpressing renin exhibit glucose intolerance and diet-genotype interactions. Frontiers in Endocrinology, 2013 Jan 7;3:166

  16. Siriwardhana N, Kalupahana NS, Cekanova M, Lemieux M, Greer B, Moustaid- Moussa N. Modulation of adipose tissue inflammation by bioactive food compounds. Journal of Nutritional Biochemistry, 2013 Apr;24(4):613-23

  17. Carroll WX, Kalupahana NS, Booker SL, Siriwardhana N, Lemieux M, Saxton AM, Moustaid-Moussa N. Angiotensinogen gene silencing reduces markers of lipid accumulation and inflammation in cultured adipocytes. Front Endocrinol (Lausanne). 2013;4:10.

  18. Somasundaram NP, Wijeyaratne CN, De Silva S, Siribaddana S, Illangasekera U, Rajaratnam H, Katulanda P, Bulugahapitiya U, Siyambalapitiya S, Antonypillai C, Sumanatilleke M, Katulanda G, Jayawardena P, Kalupahana NS et al. Diabetes Mellitus: Glucose Control. Sri Lanka Journal of Diabetes Endocrinology and Metabolism 2013; 3(1): 45-57

  19. Abdel-Hamid T, Ankel F, Battle-Fisher M, Gibson B, Gonzalez-Parra G, Jalali M, Kaipainen K, Kalupahana NS et al. Public and health professionals’ misconceptions about the dynamics of body weight gain/loss. System Dynamics Review 2014; 30(1- 2): 58–74

  20. Somasundaram N, Rajaratnam H, Wijeyarathne C, Katulanda P, De Silva S, Wickramasinghe P, Bulugahapitiya U, Siribaddana S, Siyambalapitiya S, Antonypillai C, Sumanathilake M, Garusinghe C, Muthukuda D, Niranjala MWS, Attapattu N,  Kalupahana NS et al. Clinical guidelines: The Endocrine Society of Sri Lanka: Management of Obesity. Sri Lanka Journal of Diabetes, Endocrinology and Metabolism 2014; 1: 55-70

  21. LeMieux MJ, Kalupahana NS, Scoggin S and Moustaid-Moussa N. Eicosapentaenoic acid induces adipocyte hypotrophy and reduces adipocyte inflammation in an adiposity-independent manner. Journal of Nutrition 2015; 145(3):411-7

  22. Kalupahana NS, Jayalath T, Ralapanawa U. Prevention of non-communicable diseases- the time to act is now. Sri Lanka Journal of Medicine 2015; 24(1):1-2

  23. LeMieux MJ, Mynatt R, Kalupahana NS, Kim JH, Ramalingam L, and Moustaid- Moussa N. Inactivation of Adipose Angiotensinogen Reduces Adipose Tissue Macrophages and Increases Adipose Cell Metabolic Activity. Obesity (Silver Spring) 2016 ;24(2):359-67

  24. Somasundaram NP, Kalupahana NS. Population-based dietary approaches for the prevention of noncommunicable diseases. WHO South-East Asia J Public Health 2016; 5(1): 22–26

  25. Pahlavani M, Razafimanjato F, Ramalingam L, Kalupahana NS, Moussa H, Scoggin S, Moustaid-Moussa N. Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes. Journal of Nutritional Biochemistry. 2016;39:101-109

  26. Ramalingam L, Menikdiwela K, LeMieux M, Dufour JM, Kaur G, Kalupahana NS, Moustaid-Moussa N. The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance. Biochim Biophys Acta. 2016: S0925-4439(16)30187-9

  27. Shi LZ, Zeng H, Kalupahana NS, Neale G and Chi H. Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes. Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E67-E74.

  28. Jayawardana NWIA, Jayalath WATA, Madhujith WMT, Ralapanawa U, Jayasekera RS, Alagiyawanna SASB, Bandara AMKR, Kalupahana NS. Aging and obesity are associated with undiagnosed hypertension in a cohort of males in the Central Province of Sri Lanka: a cross-sectional descriptive study. BMC Cardiovasc Disord. 2017 Jun 21;17(1):165.

  29. Goonapienuwala BL, Agampodi SB, Kalupahana NS, Siribaddana S. Body image construct of Sri Lankan adolescents. Ceylon Med J. 2017 Mar 31;62(1):40-46.

  30. Jayawardana NW, Jayalath WA, Madhujith WM, Ralapanawa U, Jayasekera RS, Alagiyawanna SA, Bandara AM, Kalupahana NS. Lifestyle factors associated with obesity in a cohort of males in the central province of Sri Lanka: a cross-sectional descriptive study. BMC Public Health. 2017 Jan 5;17(1):27.

  31. Allen L, Ramalingam L, Menikdiwela K, Scoggin S, Shen CL, Tomison MD, Kaur G, Dufour JM, Chung E, Kalupahana NS, Moustaid-Moussa N. Effects of Delta- Tocotrienol on Obesity-Related Adipocyte Hypertrophy, Inflammation, and Hepatic Steatosis in High Fat Fed Mice. J Nutr Biochem. 2017 Oct;48:128-137.

  32. Pahlavani M, Kalupahana NS, Ramalingam L, Moustaid-Moussa N. Regulation and Functions of the Renin-Angiotensin System in White and Brown Adipose Tissue. Compr Physiol. 2017 Sep 12;7(4):1137-1150.

  33. Wijayatunga NN, Pahlavani M, Kalupahana NS, Kottapalli KR, Gunaratne PH, Coarfa C, Ramalingam L, Moustaid-Moussa N. An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice. Oncotarget. 2018 Jan 13;9(10):9246-9261.

  34. Albracht-Schulte K, Kalupahana NS, Ramalingam L, Wang S, Rahman SM, Robert-McComb J, Moustaid-Moussa N. Omega-3 fatty acids in obesity and metabolic syndrome: a mechanistic update. J Nutr Biochem. 2018 Aug;58:1-16.

  35. Wijetunge S, Ratnayake RMCJ, Kotakadeniya HMSRB, Rosairo S, Albracht-Schulte K, Ramalingam L, Moustaid-Moussa N, Kalupahana NS. Association between serum and adipose tissue resistin with dysglycemia in South Asian women. Nutr Diabetes. 2019 Feb 18;9(1):5

  36. Pahlavani M, Ramalingam L, Miller EK, Scoggin S, Menikdiwela KR, Kalupahana NS, Festuccia WT, Moustaid-Moussa N. Eicosapentaenoic Acid Reduces Adiposity, Glucose Intolerance and Increases Oxygen Consumption Independently of Uncoupling Protein 1. Mol Nutr Food Res. 2019 Jan 18:e1800821

  37. Pahlavani M, Wijayatunga NN, Kalupahana NS, Ramalingam L, Gunaratne PH, Coarfa C, Rajapakshe K, Kottapalli P, Moustaid-Moussa N. Transcriptomic and microRNA analyses of gene networks regulated by eicosapentaenoic acid in brown adipose tissue of diet-induced obese mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Dec;1863(12):1523-1531

  38. Albracht-Schulte K, Gonzalez S, Jackson A, Wilson S, Ramalingam L, Kalupahana NS, Moustaid-Moussa N. Eicosapentaenoic Acid Improves Hepatic Metabolism and Reduces Inflammation Independent of Obesity in High-Fat-Fed Mice and in HepG2 Cells. Nutrients. 2019 Mar 12;11(3). pii: E599. doi: 10.3390/nu11030599.

  39. Menikdiwela KR, Ramalingam L, Allen L, Scoggin S, Kalupahana NS, Moustaid-Moussa N. Angiotensin II Increases Endoplasmic Reticulum Stress in Adipose Tissue and Adipocytes. Sci Rep. 2019 Jun 11;9(1):8481

  40. Albracht-Schulte K, Rosairo S, Ramalingam L, Wijetunge S, Ratnayake R, Kotakadeniya H, Dawson JA, Kalupahana NS, Moustaid-Moussa N. Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women. Diabetes Metab Syndr Obes. 2019 Jun 10;12:863-872

  41. Senarath U, Katulanda P, Fernando DN, Kalupahana NS, Partheepan K, Jayawardena R, Katulanda G, Dibley MJ. mHealth nutrition and lifestyle intervention (mHENAL) to reduce cardiovascular disease risk in a middle-aged, overweight and obese population in Sri Lanka: Study protocol for a randomized controlled trial. Contemp Clin Trials Commun. 2019 Sep 19;16:100453

  42. Goonapienuwala BL, Agampodi SB, Kalupahana NS, Siribaddana S. Body image perception and body dissatisfaction among rural Sri Lankan adolescents; do they have a better understanding about their weight? Ceylon Medical Journal 2019 Sep 30;64(3):82-90

  43. Fonseka S, Subhani B, Wijeyaratne CN, Gawarammana IB, Kalupahana NS, Ratnatunga N, Rosairo S, Kumarasiri PV. Association between visceral adiposity index, hirsutism and cardiometabolic risk factors in women with polycystic ovarian syndrome: A cross-sectional study. Ceylon Medical Journal 2019 Sep 30;64(3):111-117

  44. Fonseka S, Bandara DDJ, Wijeyaratne CN, Gawarammana IB, Kalupahana NS, Ratnatunga N, Rosairo S, Kumarasiri PV. Effects of Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel Alone and in Combination with Low-Dose Metformin on Glucose and Lipid Homeostasis and Androgenic Hormone Profile in Hirsute Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Triple-Dummy Study Journal of Biosciences and Medicines 7 (8), 13-26

  45. Somasundaram N, Ranathunga I, Gunawardana K, Ahamed M, Ediriweera D, Antonypillai CN, Kalupahana N. High Prevalence of Overweight/Obesity in Urban Sri Lanka: Findings from the Colombo Urban Study. J Diabetes Res. 2019 Nov 22;2019:2046428.

  46. Fonseka S, Wijeyaratne CN, Gawarammana IB, Kalupahana NS, Rosairo S, Ratnatunga N and Kumarasiri R. Effectiveness of Low-dose Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel with and without Metformin on Hirsutism in Polycystic Ovary Syndrome: A Randomized, Double-blind, Triple-dummy Study. J Clin Aesthet Dermatol. 2020;13(7):18–23

  47. Menikdiwela KR, Ramalingam L, Rasha F, Wang S, Dufour JM, Kalupahana NS, Sunahara KKS, Martins JO, Moustaid-Moussa N. Autophagy in metabolic syndrome: breaking the wheel by targeting the renin-angiotensin system. Cell Death Dis. 2020 Feb 3;11(2):87

  48. Claycombe-Larson KJ, Alvine T, Wu D, Kalupahana NS, Moustaid-Moussa N, Roemmich JN. Nutrients and Immunometabolism: Role of Macrophage NLRP3. Journal of Nutrition. 2020 Apr 9. pii: nxaa085. doi: 10.1093/jn/nxaa085

  49. Kalupahana NS, Goonapienuwala BL and Moustaid-Moussa N. Omega-3 Fatty Acids and Adipose Tissue: Inflammation and Browning. Annual Review of Nutrition,  2020 Jun 16.

  50. Yosofvand M, Liyanage S, Kalupahana NS, Scoggin S, Moustaid-Moussa N, Moussa H. AdipoGauge software for analysis of biological microscopic images. Adipocyte. 2020 Dec;9(1):360-373.

  51. Menikdiwela KR, Ramalingam L, Abbas MM, Bensmail H, Scoggin S, Kalupahana NS, Palat A, Gunaratne P, Moustaid-Moussa N. Role of microRNA 690 in Mediating Angiotensin II Effects on Inflammation and Endoplasmic Reticulum Stress. Cells. 2020 May 26;9(6):1327

  52. Ramalho T, Pahlavani M, Kalupahana N, Wijayatunga N, Ramalingam L, Jancar S, Moustaid-Moussa N. Eicosapentaenoic Acid Regulates Inflammatory Pathways through Modulation of Transcripts and miRNA in Adipose Tissue of Obese Mice. Biomolecules. 2020 Sep 7;10(9):E1292
 
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