Prof. C.N.R.A. Alles
Professor in Biochemistry
 
International Peer Reviewed Publications
  1. Experimental In-vivo animal models for asthma/ allergic asthma: importance and documented parameters- A review. Hewa Dikkumburage Tharindu Madhuranga, C.N.R.A. Alles, The Journal of Phytopharmacology. 2024:13(1):49-63

  2. Responses of Human Osteosarcoma Cells to Hydroxyapatite Nano-Particles on TiO2 Surfaces; an In-Vitro Study. Premachandra TN. Wijesinghe WPSL, Rajapakse RPVJ, Rajapakse RMG, Alles CNRA, Herath HMTU. J Nanomed. 2022: 5(1): 1053. ISSN: 2578-8760.

  3. A preliminary analysis of renal infiltrating cells in acute tubular injury induced by water treated with high fluoride and high hardness in rat model. Perera T, Ranasinghe S, Alles N, Waduge R. Christoph D. Res. J. Biotech. 2021:16: 178-185

  4. Experimental rat model for acute tubular injury induced by high water hardness and high water fluoride: efficacy of primary preventive intervention by distilled water administration. Perera T, Ranasinghe S, Alles N, Waduge R. BMC Nephrology. 2020: 21:103, https://doi.org/10.1186/s12882-020-01763-3.

  5. Exposure to fluoride significantly decrease the cell membrane integrity and mitochondrial activity in murine renal cells, Perera T, Godakumara K, Ranasinghe S, Alles N, Int. J. Adv. Res. 2020: 8, 735-743.

  6. Positive and negative regulators of osteoclast apoptosis. Soysa NS, Alles N. Bone Reports. 2019: 11:100225, https://doi.org/10.1016/j.bonr.2019.100225.

  7. Efficacy of articaine vs lignocaine in maxillary and mandibular infiltration and block anesthesia in the dental treatments of adults: A systematic review and meta-analysis. Soysa NS, Soysa IB, Alles N. J Investig Clin Dent. 2019;18:e12404. doi: 10.1111/jicd.12404

  8. Fluoride concentration and stability in commonly used dentifrices in Sri Lanka. Soysa NS, Cury JA, Alles CNRA. Brazilian Journal of Oral Sciences. 2018; 17: e181244

  9. The role of IL-3 in bone. Soysa NS, Alles N. J Cell Biochem. 2018;1‐9. doi: 10.1002/jcb.27956. SCI expanded. Impact factor 3.448

  10. Effect of fluoride on major organs with the different time of exposure in rats. Perera T, Ranasinghe S, Alles N, Waduge R, Environmental Health and Preventive Medicine 2018; 23:17; https://doi.org/10.1186/s12199-018-0707-2

  11. Osteoclast function and bone-resorbing activity: An overview. Soysa NS, Alles N. Biochem Biophys Res Commun. 2016;476(3):115-20. SCI expanded. Impact factor 4.370

  12. A pilot study on attitudes, knowledge and behaviour towards dental diseases among grade medical officers in Kandy district, Sri Lanka. Soysa NS, Alles N. The Journal of Dentist. 2016: Article in press.

  13. The polyethylene glycol crosslinking of cholesterol-bearing pullulan nanogels increased the inhibitory effects of the W9 synthetic peptide on bone loss in a murine bone resorption model. Toshimi Sato, Neil Alles, Masud Khan, Kenichi Nagano, Maroko Takahashi, Yukihiko Tamura, Asako Shimoda, Keiichi Ohya, Kazunari Akiyoshi, Kazuhiro Aoki. International Journal of Nanomedicine. 2015:10 3459–3473. Journal impact factor: 4.195

  14. NF-?B RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. Setsuko Mise-Omata, Neil Alles, Taro Fukazawa, Kazuhiro Aoki, Keiichi Ohya, Eijiro Jimi, Yuichi Obata and Takahiro Doi. International Immunology. 2014;26(11):607-18. Journal impact factor: 3.181

  15. Gelatin hydrogel carrier with the W9-peptide elicits synergistic effects on BMP-2-induced bone regeneration. Md. AbdullahAlMamun, Md.AbdullaAlMasudKhan, Neil Alles, MakotoMatsui, YasuhikoTabata, KeiichiOhya, KazuhiroAoki. Journal of Oral Biosciences. 2013: 55:217-23

  16. Disruption of NF-kB1 prevents bone loss caused by mechanical unloading. Nakamura H, Aoki K, Masuda W, Alles N, Nagano K, Fukushima H, Osawa K, Yasuda H, Nakamura I, Mikuni-Takagaki Y, Ohya K, Maki K, Jimi E. J Bone Miner Res. 2013;28(6):1457-67. Journal impact factor: 7.056

  17. A small peptide inhibitor of inflammatory bone resorption promotes BMP-2- induced bone formation. Abdulla Al Masud Khan, Neil Alles, Niroshani S. Soysa, Md. Abdullah Al Mamun, Kenichi Nagano, Risako Mikami, Yuriko Furuya, Hisataka Yasuda, Keiichi Ohya, KazuhiroAoki. Journal of Oral Biosciences. 2013;55(1):47-54.

  18. Osteoclast formation and differentiation; an overview. Soysa NS, Alles N*, Aoki K, Ohya K. J Med Dent Sci. 2012;59(3):65-74. * Corresponding Author

  19. Peptide-based delivery to bone. Aoki K, Alles N, Soysa NS, Ohya K. Adv Drug Deliv Rev. 2012;64(3):1220-38. Journal impact factor: 14.608

  20. A structural modulator of tumor necrosis factor type 1 receptor promotes bone formation under lipopolysaccharide-induced inflammation in a murine tooth extraction model. Nakachi H, Aoki K, Tomomatsu N, Alles N, Nagano K, Yamashiro M, Zhang H, Murali R, Greene MI, Ohya K, Amagasa T.European Journal of Pharmacology. 2012; 697(1-3):132-8. Journal impact factor: 2.728

  21. Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice. Alles N, Soysa NS, Hayashi J, Khan M, Shimoda A, Shimokawa H, Ritzeler O, Akiyoshi K, Aoki K, Ohya K. Endocrinology. 2010;151(10):4626-34. Journal impact factor: 4.459

  22. The Pivotal Role of the Alternative NF-kappaB Pathway in Maintenance of Basal Bone Homeostasis and Osteoclastogenesis. Soysa NS, Alles N, Weih D, Lovas A, Mian AH, Shimokawa H, Yasuda H, Weih F, Jimi E, Ohya K, Aoki K. J Bone Miner Res. 2010;25(4):809-18.Journal impact factor: 7.056
    *Soysa NS and Alles N contributed equally.
    **Received a commendation from Faculty of 1000 which is an award-winning online service that highlights and evaluates the most interesting papers published in the biological sciences.

  23. Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss. Alles N, Soysa NS, Hussain MD, Tomomatsu N, Saito H, Baron R, Morimoto N, Aoki K, Akiyoshi K, Ohya K. Eur J Pharm Sci. 2009 ;37(2):83-8. Journal impact factor: 3.536

  24. The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor- α -induced bone resorption lacunae on mouse calvariae. Nagano K, Alles N, Mian AH, Shimoda A, Morimoto N, Tamura Y, Shimokawa H, Akiyoshi K, Ohya K, Aoki K. J Bone Miner Metab. 2011;29(6):671-81. Journal impact factor: 2.268

  25. Defective NIK in aly/aly mice prevents bone resorption induced by local injection of Lipopolysaccharide. Soysa NS, Alles N, Aoki K, Ohya K. J Perio Res. 2011;46(2):280-4. *Received a commendation from Target Intelligence Service (TIS), a database used by pharmaceutical companies worldwide to identify ground breaking research of relevance to their own work on potential drug targets. Journal impact factor: 1.686

  26. Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation. Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, Doi T, Aoki K, Alles N, Ohya K, Hosokawa R, Jimi E. J Bone Miner Res. 2010;25(5):1058-67. Journal impact factor: 7.056

  27. Increased bone mass in adult prostacyclin-deficient mice. Nakalekha C, Yokoyama C, Miura H, Alles N, Aoki K, Ohya K, Morita I. J Endocrinol. 2010;204(2):125-33. Journal impact factor: 3.568

  28. Three-dimensional characterization of osteoclast bone-resorbing activity in the resorption lacunae. Soysa NS, Alles N, Aoki K, Ohya K. J Med Dent Sci. 2009 ;56(3):107-12.

  29. Inhibition of the classical NF-kappaB pathway prevents osteoclast bone-resorbing activity. Soysa NS, Alles N, Shimokawa H, Jimi E, Aoki K, Ohya K. J Bone Miner Metab. 2009;27(2):131-9. Journal impact factor: 2.268

  30. NF-kappaB functions in osteoclasts. Soysa NS, Alles N. Biochem Biophys Res Commun. 2009 ;378(1):1-5. Journal impact factor: 2.648

  31. LPS-induced inhibition of osteogenesis is TNF-alpha dependent in a murine tooth extraction model. Tomomatsu N, Aoki K, Alles N, Soysa NS, Hussain A, Nakachi H, Kita S, Shimokawa H, Ohya K, Amagasa T. J Bone Miner Res. 2009;24(10):1770-81.Journal impact factor: 7.056

  32. Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo. Hussain Mian A, Saito H, Alles N, et al. J Bone Miner Metab. 2008; 26:469-77.Journal impact factor: 2.268

  33. Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2 (-/-) mice. Gil-Henn H, Destaing O, Sims NA, Aoki K, Alles N, et al. J Cell Biol. 2007; 178:1053-64.Journal impact factor: 12.480

  34. Three-Dimensional Measurements of Bone Resorption Lacunae Reveal Inhibition of Osteoclast Activity by TNF-a Antagonist In Vitro. Hiroaki Saito, Niroshani Soysa, Neil Alles, Kazuhiro Aoki, Keiichi Ohya. Dentistry in Japan. 2006;42: 33-37.
Local Publications
  1. Nutritional properties, antioxidant potential and anti-diabetic effect of raw and processed Artocarpus nobilis (Ceylon breadfruit) seeds. S.M. Sewwandi, B.C. Jayawardana, R. Sivakanesan, S. Wijesundara, N. Alles, N. Marikkar and R. Liyanage. Ceylon Journal of Science. 2022; 51(4): 481-491

  2. Clinical relevance of understanding liver biochemical markers in managing dental patients. Alles N, Soysa NS. Sri Lanka Dental Journal. 2016; 46(03): 88-95

  3. The importance of knowing the patient’s clotting profile before dental treatment. Alles N, Soysa NS. Sri Lanka Dental Journal. 2016; 46(01): 05-13

  4. Stress: A friend or foe? Soysa NS, Alles N. The General Dental Practitioner. 2014;31:38-41.

  5. Prevalence of Candida in saliva and root canals of teeth associated with apical periodontitis. Soysa NS, Fernando HN, Alles N, Wijeyeweera RL, Wettasinghe KA, Panagoda GJ. Sri Lanka Dental Journal 2010;40(02-03):54-60
Feature articles in scientific magazines
  1. Single agent therapy for dual effect in osteoporosis. Hanthana vision, Research magazine of the University of Peradeniya, University of Peradeniya. 2016; 2(2): 14-15
Presentations at International scientific meetings
Full paper publications
    1. Assessing osteoclast function by 3-D measurements of resorption lacunae. C.N.R.A Alles, H.N.S. Soysa. Annual research Journal of SLSAJ, Issue 08.
Abstract publications
  1. Maternal Risk Factors for Gestational Diabetes Mellitus: Results from a Tertiary Care Cohort from Kandy District, Sri Lanka. Ambagaspitiya AWDT, Tennakoon S, Ratnayake RMCJ, Alles CNRA, Ranasinghe JGS. (2025) 2nd International Conference on Recent Innovations in Biological, Chemical & Clinical Sciences 2025 (RIBCCS), Malaysia.

  2. Effect of energy and macronutrient intake during early pregnancy on large-for-gestational age babies. Ambagaspitiya AWDT, Alles CNRA. (2024) 8th Conference on Sri Lanka - Japan Collaborative Research, Sri Lanka - Japan Study Centre, University of Peradeniya, Sri Lanka.

  3. Effect of Energy and Macronutrient Intake During Early Pregnancy on Large-for-Gestational Age Babies. D. Ambagaspitiya, N. Alles. (2023) International Conference on Sri Lanka – Japan Collaborative Research (SLJCR).

  4. Gestational diabetes mellitus versus maternal serum copper and zinc levels: results from a case control analysis. Ambagaspitiya AWDT, Tennakoon S, Ratnayake RMCJ, Alles CNRA, Ranasinghe JGS. (2023) The 5th International Conference on Food, Nutrition, Health & Lifestyle. Kuala Lumpur, Malaysia.

  5. Pharmacological inhibition of alternative NF-KB pathway ameiliorates periodontitis after ovariectomy in a murine model. N.S. Soysa, E.G.C.N. Premathilake, C.N.R.A. Alles. (2023) Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  6. A study on the effect of coconut lipids on glucose metabolism in rats and cell culture models. Perera MCN, Fernando PHP, Alles CNRA, Yalegama C. (2023) Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  7. Predictors of Delivering Large-for-Gestational Age Babies: Pre-pregnancy Body Mass Index Versus Gestational Weight Gain. D. Ambagaspitiya, S. Tennakoon, D.T. Ranasinghe, N. Alles, J.G.S. Ranasinghe. (2023) Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  8. Glucose uptake by MCF-7 cells upon supplementation of culture medium with fatty acids in virgin coconut oil or soya oil. Perera MCN, Fernando PHP, Alles CNRA, Prasasdine MGTM, Yalegama C. (2023) Annual Research Conference of PeMSARC’23, Peradeniya Medical School.

  9. Effect of NF-ƙB inhibitor, SN52 on RANKL induced osteoclastogenesis. Prasadinie M.G.T.M, Premathilaka E.G.C.N, Alles C.N.R.A. (2022/2023) 10th Annual Scientific Sessions of The Sri Lankan Association for Laboratory Animal Science (SLALAS).
    *Awarded for best oral presentation.

  10. Effect of NF-ƙB inhibitor, SN52 on maintaining calcium and phosphorus content of bone in an ovariectomized mouse model. Prasadinie M.G.T.M, Soysa H.N.S, Alles C.N.R.A. (2021/2022) 9th Annual Scientific Sessions of The Sri Lankan Association for Laboratory Animal Science (SLALAS).

  11. Red cell fragility of non-diabetic and diabetic rats fed with virgin coconut oil, soya oil and water. Perera MCN, Fernando PHP, Alles CNRA, Yalegama C. (2022) Annual Research Conference of PeMSARC’23, Peradeniya Medical School.

  12. Improvement of glucose tolerance in nondiabetic rats compared to diabetes-induced rats by feeding virgin coconut oil or soya oil. Perera MCN, Fernando PHP, Alles CNRA, Yalegama C. (2021) Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  13. Phenolic content and antioxidant activities of raw and processed Artocarpus Nobilis (Ceylon breadfruit) seeds in comparison with Almond, Pistachio and Cashew. SM Sewwandi, R Sivakanesan, S Wijesundara, N Alles, R Liyanage. (2021) Postgraduate Institute of Science Research Congress (PGIS RESCON 2021).

  14. The establishment and characterization of a LPS-introduced periodontitis murine model. NMAW Nishshanka, EGCN Premathilaka, CNRA Alles, NS Soysa. (2019) Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  15. Evaluation of osteoblast-like cell response to hydroxyapatite nano-particles deposited on self-formed TiO2 thin layer on Ti surface. Premachandra WGTN, Wijesinghe WPSL, Thilakarathne MGGSN, Rajapakse RMG, Alles CNRA, Rajapakse RPVJ, Herath HMTU. (2018) Intrnational Conference on Nano Technology and Nano Engineering, Paris, France.

  16. Potential link between groundwater hardness with fluoride and chronic kidney disease of unknown etiology (CKDu) in Sri Lanka using rats as an experimental model. Perera WTR, Ranasinghe JGS, Waduge R, Alles, N. International conference on Chronic kidney disease of unknown etiology 2018;11.

  17. Aqueous extract of Salacia reticulata leaves can increase bone formation in-vitro. Godakumara K,  Premathilake C, Fernando P, Soysa N, Alles N. (2017) International Symposium on Traditional and
    Complementary Medicine, Educational Exhibition & Trade Fair (Tradmed).

  18. Establishment of reference ranges for serum C-telopeptide cross-link of type 1 collagen levels in Sri Lankan population. Godakumara GKM, Premathilake C, Ralapanawa DMPUK, Illangasekera Y, Soysa HNS, Fernando PHPF, Alles N*. (2017). Annual research session-University of Peradeniya, Sri Lanka (iPURSE).
    * Corresponding Author

  19. Study on effect of selected plant extracts on the content of some trace elements in femur in overiectomized mice. Premathilaka C Godakumara GKM, Perera MCN, Soysa HNS, Alles N and Fernando PHPF (2017). Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  20.  Knowledge and self-foot care practices among diabetic patients, attending general hospital, mannar, sri lanka. Pieris HRR, Soysa HNS, Alles CNRA. (2016). Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  21. Attitudes towards complementary and alternative medicine among second year medical, dental, nursing and physiotherapy students at the university of peradeniya. Gunaratne BRRN, Alles CNRA, Soysa NS. (2016). Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  22. Salacia reticulata (kothala himbutu) and Psychotria sarmentosa (gonika) extracts ameliorates ovariectomy induced bone destruction. Godakumara GKM, Fernando PHP, Soysa HNS, Alles CNRA*. (2016). Annual research session-University of Peradeniya, Sri Lanka (iPURSE). * Corresponding Author

  23. Pilot study on attitudes, knowledge and behaviour towards dental diseases among grade medical officers in Kandy district, Sri Lanka. N.R. A. Alles, T. Dissanayake, K. Rathnayake, N.S. Soysa (2015) .World Dental Federation, Annual World Dental Congress (FDI), Bangkok, Thailand.

  24. Assessment of soluble fluoride concentrations in fluoridated tooth pastes marketed in Sri Lanka. N.S. Soysa, N. Alles (2015) .World Dental Federation, Annual World Dental Congress (FDI), Bangkok, Thailand. 

  25. Availability of total, soluble and ionic fluoride concentration in commonly used dentifrices in Sri Lanka. N.S. Soysa, N. Alles, L. Tenuta, J. Cury (2015). Asia Pacific Dental Congress (APDC), Singapore.

  26. Elucidation of the relationship between a bone turnover marker, CTX, and some trace minerals. G.K. M. Godakumara, E.G.C.N. Premathilake, N. Alles*, P. H. P. Fernando, N.S. Soysa (2015). Annual research session-University of Peradeniya, Sri Lanka (iPURSE). * Corresponding Author

  27. Pilot study on changes in some trace elements in long bones in ovariectomized mice. E.G.C.N. Premathilake, G.K.M. Godakumara, P. H. P. Fernando, N. Alles, N.S. Soysa (2015). Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  28. Quantitative analysis of micromineral contents in six specieses of marine macro algae – a preliminary study. L.A. wanasinghe, E.G.C.N. Premathilake, P. H. P. Fernando, N. Alles, M.C.N. Perera, W.D.M.C. Wickramanayake, R.P.V.J. Rajapakse (2015). Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  29. Metachromatic activity of some species of marine macro algae found in the southern Sri Lankan coast. L.A. wanasinghe, P. H. P. Fernando, N. Alles, A.M.P.S.T. Bandara, R.P.V.J. Rajapakse (2015). Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  30. Rankl-antagonist-peptide increases bone formation in vitro and in vivo. N. Alles*, N.S. Soysa, P. H. P. Fernando, K. Ohya, K. Auki (2014). Annual research session-University of Peradeniya, Sri Lanka (iPURSE). * Corresponding Author

  31. Local administration of LPS on calvariae cause delayed effect on bone mineral density in long bones of mice. N.S Soysa, N. Alles, K. Aoki and K. Ohya (2013). DI/CDA/SLDA Joint International Conference, Colombo, Sri Lanka.

  32. LPS causes early local bone-resorption and increases bone mineral density in mice. N. Soysa, N. Alles, K. Aoki and K. Ohya (2013). 91st General Session and Exhibition of International Association for Dental research (IADR), Seattle, USA.

  33. Bone resorption inhibitory peptide repairs critical size defect on calvariae in mice.N Alles, N Soysa, M Khan, Ohya K, Aoki K. (2012) Journal of Bone Mineral Reserch.

  34. RANKL-Mediated Bone Formation By TNF-alpha Antagonist Peptide. M. Khan, N. Alles, A. Mamun, K. Nagano, K. Ohya, and K. Aoki(2012) Journal of Dental Research.

  35. TNF- α antagonist peptide increases ectopic bone formation under RANKL dependent Mechanism. M Khan, N Alles, M Mamun et al. (2012). 29th Annual Meeting of Japanese Association of bone mineral Research, Niigata, Japan

  36. An antagonist of tumor necrosis factor-a stimulates bone formation under the lipopolysaccharide induced inflammation n in a murine tooth extraction model. Kazuhiro Aoki, Hiroyuki Nakachi, Neil Alles et al. (2012). Annual Meeting of the Japanese Pharmacological Society (JPS), Kyoto, Japan

  37. BMP and gelatin carrier induced local bone formation. Mamun A. A, Khan M, Alles N, Ohya K, Aoki K (2012).The 54th Annual Meeting of The Japanese Society of Oral biology, Koriyama, Japan.

  38. Both TNF- α and RANKL antagonist peptide stimulates bone formation in TNF- α deficient mice to the same extent as in wild type mice. M Khan, N Alles, Y Furuya, et al. (2011). 33rd Annual Meeting of American Society for Bone and Mineral Research (ASBMR), San Diego, USA.

  39. A bone resorption inhibitor promotes bone formation. M Khan, N Alles, H Yasuda, et al. (2011). 59th Annual Meeting of Japanese Association for Dental Research, Hiroshima, Japan.

  40. The stimulatory effects of TNF-α and RANKL antagonist peptide W9 on bone formation. M Khan, N Alles, K Nagano et al. (2011). 31st Annual Meeting of the Japanese Society for Bone morphometry. Gifu, Japan.

  41. The stimulatory effects of NFkB inhibitor on bone formation.  Kazuhiro Aoki, Masud Khan, Neil Alles, et al. (2011). Annual Meeting of the Japanese Pharmacological Society (JPS), Yokohama, Japan

  42. Pharmacological Suppression of NF-kB increase bone formation in vitro and in vivo. N.S Soysa, N. Alles. (2010) 32nd Asia Pacific Dental Congress. Colombo, Sri Lanka.

  43. Pharmacological Inhibition of NF-kB For Bone Formation In vitro And In vivo NS. Soysa , N Alles , J Hayashi et al.  (2010). 88th General Session and Exhibition of International Association for Dental research (IADR), Barcelona, Spain.

  44. The effect of anti-bone resorption peptide with nanogel sheet as a peptide carrier: comparison to a nanogel cross-linking hydrogel. K Aoki, N Alles, M Khan et al. (2010), Osaka, Japan.   

  45. The control release of TNF-a is necessary to mimic LPS-induced bone resorption on calvaria. Kenchi Nagano, Kazuhiro Aoki, Hussain Mian, Neil Alles et al. (2009). The 82nd Annual Meeting of the Japanese Pharmacological Society (JPS), Yokohama, Japan.

  46. Lack of precursor p100 of NF-kB2 causes osteopenia in mice. Niroshani Soysa, Neil Alles, Kazuhiro Aoki et al. (2009). 29th Annual Meeting of Japanese Society for Bone Morphometry, Osaka, Japan.

  47. NF-kB–inducing kinase is necessary for LPS-induced bone resorption. N Alles, N Soysa, K Aoki, et al. (2009). 87th General Session and Exhibition of International Association for Dental research (IADR), Miami, USA.

  48. Inhibition of IKK-b blocks osteoclast formation and activity. K.Ohya, N Soysa, N Alles, K Aoki. (2009). 57th Annual Meeting of the Japanese Association for Dental Research (JADR), Wuhan, China.

  49. Polysaccharide nanogel delivery of TNF-α antagonist-peptide prevents systemic bone loss. N Alles, N Soysa, N Morimoto, et al (2009). Research Day, Faculty of Dentistry, University of Toronto, Canada.

  50. The role of TNFR2 on TNF-α induced bone resorption. Nagano K, Aoki K,Neil A, Ohya K (2009) 51st annual meeting of Japanese association for oral biosciences. Niigata, Japan.

  51. TNF-α induced bone resorption model using CHP nanogel in mice. K.Nagano, K. Aoki, A.H. Mian, N. Alles, A. Shimoda, N. Morimoto, K. Akiyoshi and K. Ohya. (2008). The 56th Annual Meeting of the JADR, Nagoya, Japan.

  52. Defective alternative pathway of NF-kB causes mild osteopetrosis in mice. N Soysa, N Alles, K Aoki, H. Shimokawa, E Jimi , K Ohya (2008). 86th General Session and Exhibition of the International Association for Dental Research (IADR), Toronto, Canada.

  53. NIK mutation in aly/aly mice causes osteopetrosis and reduces RANKL induced osteoclasogenesis. N.S Soysa, C.N.R Alles, AH Mian, H Yasuda, E Jimi , H. Shimokawa, K Aoki, K Ohya (2008). The 2nd International Conference on Osteoimmunology, Rhodes, Greece.

  54. Nanogel cross-linking hydrogel as a drug delivery system for the peptide type of drugs. C.N.R.A Alles, N.S. Soysa, K.Aoki, K.Ohya (2008).The 50th Annual Meeting of the Japanese Society of Oral Biology, Tokyo, Japan.

  55. Non-canonical NF-kB regulates osteoclast formation and function. N.S Soysa, C.N.R Alles, K Aoki, H. Shimokawa, E Jimi, K Ohya (2008).The 81th Annual Meeting of the Japanese Pharmacological Society, Yokohama, Japan.

  56. Nanogel cross-linking hydrogel as a drug delivery system for tumor necrosis factor-alpha antagonist. C.N.R Alles, N.S Soysa, A.H Mian, N. Tomamatsu, N. Morimoto, U. Hasegawa, S. Sawada, Y. Tada, K.Akiyoshi, K.Ohya, K.Aoki (2008).30th Annual Meeting of American Society for Bone and Mineral Research (ASBMR), Montréal, Quebéc, Canada.

  57. LPS-induced inhibition of osteoclastogenesis is TNF-α dependant. N. Tomomatsu, K.Aoki, M. A. Hussain, C.N.R Alles , et al. (2008). 30th Annual Meeting of American Society for Bone and Mineral Research (ASBMR), Montréal, Quebéc, Canada.

  58. Defective NIK causes impaired osteoclastogenesis and mild osteopetrosis in mice.　N.S Soysa, N. Alles, K Aoki, H.Shimokawa, E Jimi, K Ohya (2008). The 55th Annual Meeting of the JADR, Tsurumi, Japan.

  59. Effects of Treadmill running load on bone mass in p50 deficient mice. K. Aoki, H. Fukushima, N. A. Alles, et al. (2008). 26th Annual Meeting of Japanese Society for Bone and Mineral Research (JSBMR), Osaka, Japan.

  60. CHP nanogel and W9 peptide complex ameliorates bone resorption in the low Ca murine model.C.N.R Alles, A. H. Mian, K Aoki, K Ohya (2007).The 80th Annual Meeting of the Japanese Pharmacological Society, Nagoya, Japan.

  61. Canonical NF-kB pathway mediates Osteoclast Bone resorption activity. N.S Soysa, C.N.R Alles, K Aoki, E Jimi, K Ohya (2007). 29th Annual Meeting of American Society for Bone and Mineral Research (ASBMR), Hawaii, USA.

  62. TNFR1 and 2 differentially regulates inflammatory bone resorption induce by LPS in vivo. M.H Mian, K Aoki, N Alles, et al (2007). 29th Annual Meeting of ASBMR, Hawaii, USA.

  63. Use of Nanogels as a drug delivery system for tumor necrosis factor-alpha antagonist in murine bone resorption model.C.N.R Alles, A.H Mian, N.S Soysa, H.Saito, K.Aoki, K.Akiyoshi, K.Ohya (2007). 29th Annual Meeting of American Society for Bone and Mineral Research (ASBMR), Hawaii, USA.

  64. The protecting role of TNFR2 on bone resorption. Mian M, Aoki K, Alles N, Soysa N, Nagano K, Ohya K (2007). The 49th Annual Meeting of The Japanese Society of Oral biology, Sapporo, Japan.

  65. Applications of CHP Nanogel as a drug delivery system for tumor necrosis factor-alpha peptide antagonist in murine bone resorption model. C.N.R.A Alles, A.Mian, N.S. Soysa, K.Aoki, K.Akiyoshi, K.Ohya (2007).27th Annual Meeting of Japanese Society for Bone Morphometry, Nagasakii, Japan.

  66. The protecting role of TNFR2 on bone resorption. Mian M, Aoki K, Alles N, et al. (2007). 49th Annual Meeting of The JSOB, Sapporo, Japan.

  67. LPS-induced bone resorption is increased in TNFR2 KO mice in-vivo. M.H Mian, K Aoki, N Alles, et al. (2007). 55th Annual Meeting of JADR, Tsurumi, Japan.

  68. Inhibition of IKKb-NEMO binding blocks osteoclast activity and actin-ring formation. N.Soysa, C.Alles, H. Saito, K.Aoki, E.Jimi, K.Ohya (2006). 84th General Session and Exhibition of the International Association for Dental Research (IADR), Brisbane, Australia.

  69. Subcutaneous injection of W9 peptide and CHP nanogel complex inhibits the decrease of BMD induced by a low Ca feeding in mice. C.N.R.A Alles, N.Morimoto, U.Hasegawa, A.Mian, N.S. Soysa, H. Saito, K.Aoki, R.Baron, K.Akiyoshi, K.Ohya (2006).28th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Philadelphia, Pennsylvania, USA.

  70. Pyk-/- mice are osteoporotic due to the defective regulation of microtubules and actin in osteoclasts H. Gil-Henn, O. Destaing, A Bruzzaniti, N. Left, N. Sims, K. Aoki, N. Alles, A. Sanjay, R Baron, J Schlessinger(2006).28th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Philadelphia, Pennsylvania, USA.

  71. NEMO Binding Domain (NBD) peptide inhibits the activity of osteoclasts. N.Soysa, C.Alles, H. Saito, K.Aoki, E.Jimi, K.Ohya (2005). 53rd Annual meeting Japanese Association for Dental Research, Okayama, Japan.

  72. A role of NF-kβ on unloading-induced bone loss.Nakamura H, Aoki K, Ohya K, Alles N, Nagai Y, Maki E, Jimi E.
Presentations at Local scientific meetings
Full paper publications
  1. Double burden of maternal malnutrition in a cohort of pregnant mothers from kandy district: Impact on birthweight. Abewardhana MGDK, Ambagaspitiya AWDT, Alles CNRA (2025) 47th Annual Academic Sessions of the Kandy Society of Medicine.

  2.  Maternal copper deficiency: a hidden risk factor of low birth weight. Ambagaspitiya AWDT, Tennakoon S, Alles CNRA, Ranasinghe JGS. (2024) 46th Annual Academic Sessions of the Kandy Society of Medicine.

  3.  Short term efficacy of local tetracycline delivery devices in non-surgical periodontal therapy: a meta-analysis. Soysa NS, Ambagaspitiya AWDT, Prasangika H, Alles CNRA. (2023) 45th Annual Academic Sessions of the Kandy Society of Medicine.

  4.  Does locally delivered minocycline adjunct to subgingival debridement ameliorate chronic periodontitis in smoker and non-smoker patients? Ambagaspitiya AWDT, Alles CNRA, Soysa NS. (2023) 45th Annual Academic Sessions of the Kandy Society of Medicine.

  5.  Meta analysis of short-term adjunctive effects of doxycycline on chronic periodontitis therapy. Alles CNRA, Ambagaspitiya AWDT, Soysa NS. (2023) 45th Annual Academic Sessions of the Kandy Society of Medicine.

  6.  Body mass index (BMI): a factor associated with the energy status in pregnancy. Ambagaspitiya AWDT, Tennakoon S, Ratnayake RMCJ, Alles CNRA, Ranasinghe JGS. (2023) 45th Annual Academic Sessions of the Kandy Society of Medicine.

  7.  Macronutrient intake in a cohort of pregnant mothers attending antenatal clinics at the teaching hospital Peradeniya. Ambagaspitiya AWDT, Tennakoon S, Ratnayake RMCJ, Alles CNRA, Ranasinghe JGS. (2023) 45th Annual Academic Sessions of the Kandy Society of Medicine.

  8. Body Mass Index: a Factor that Determines Maternal Serum Calcium and Copper Levels in Pregnancy. Ambagaspitiya AWDT, Tennakoon S, Ratnayake RMCJ, Alles CNRA, Ranasinghe JGS. (2023). 4th Conference of The College of Biochemists of Sri Lanka.
    *Awarded for best oral presentation.

  9. A novel IKK-β inhibitor S1627 blocks osteoclastogenesis and bone resorbing activity in vitro and in vivo. N.S Soysa, N. Alles, K. Aoki and K. Ohya. Proceedings of Peradeniya university research sessions, Sri lanka. 2010; 15 :23-25

  10. Deletion of precursor p100 not P52 cause osteopenia in mice. N.S Soysa, N. Alles, K. Aoki and K. Ohya. Proceedings of Peradeniya university research sessions, Sri lanka. 2010; 15 :35-36
Abstract publications
  1. Effect of nf-ƙb inhibitor, sn52 on osteoclastogenesis and functions of mature osteoclasts. Prasadinie, M.G.T.M, Premathilaka, E.G.C.N, Alles, C.N.R.A. (2023). Sri Lankan Association for Laboratory Animal Science (SLALAS).

  2. Red cell fragility of non-diabetic and diabetic rats fed with virgin coconut oil, soya oil and water. Perera, M.C.N, Fernando, P.H.P, Alles,C.N.R.A, Yalegama C. (2022). Peradeniya Medical School Annual Research Conference (PeMSARC’22).

  3. Improvement of Glucose Tolerance in Nondiabetic Rats by feedingVirgin Coconut Oil or Soya Oil. M.C.N.Perera, N. Alles, PHP Fernando (2021). Annual research session-University of Peradeniya, Sri Lanka (iPURSE).

  4. Phenolic content and antioxidant activities of raw and processed Artocarpus nobilis (Ceylon breadfruit) seeds in comparison with almond pistachio and cashew. Sewwandi, S.M., Sivakanesan, R., Wijesundara, S., Alles, N. Liyanage R. (2021). Proceedings of PGIS research congress (RESCON) 2021, University of Peradeniya, 29th-31st October 2021, p 124.

  5. Evaluation of prebiotic activity and dietary fiber content of raw and processed Artocarpus nobilis (Ceylon breadfruit) seeds. Sewwandi, S.M., Sivakanesan, R., Wijesundara, S., Alles, N., Liyanage R. (2021).Proceeding of Young Scientist’s conferences on Multidisciplinary Research (YMCMR), National Institute of Fundamental Studies, Kandy, 21st October 2021, p 67.

  6. Evaluation of phenolic content and antioxidant activities of raw and processed artocarpus nobilis (ceylon breadfruit) seeds in comparison with almond, pistachio and cashew. S.M. Sewwandi, R. Sivakanesan, S. Wijesundara, N. Alles and R. Liyanage (2021), Proceedings of the Postgraduate Institute of Science Research Congress, Sri Lanka.

  7. Local administration of LPS on calvariae cause delayed effect on bone mineral density in long bones of mice. Soysa N.S, Alles N, Aoki K, Ohya K (2013). Sri Lanka Dental Journal.

  8. Attitudes towards complementary and alternative medicine among medical students in Sri Lanka: A pilot study. S. Bandara, N Alles, N.S. Soysa, (2013). Annual research session-University of Peradeniya, Sri Lanka.

  9. Comparison of Egg composition of village chicken and brown leghorn breeds. CMB Dematawewa, N.A Alles, GLLP Silva (2000) 56th annual session, Sri Lanka Association for the Advancement of Science. Colombo, Sri Lanka.

  10. Relationship between fluoride intake and kidney cell viability. W T R Perera, J G S Ranasinghe, K Godakumara, N Alles, R Waduge (2017) annual sessions, Postgraduate Institute of Science Research Congress, University of Peradeniya. 
Books Published
  1. Biochemistry made easy. ISBN 978-955-30-6736-4
  2. Methods in Bone Research. ISBN 978-955-38052-0-1
Any other particulars
Research expertise
  • Strong background in animal models, histopathology and histomorphometry (bone densitometry (DEXA, pQCT), bone imaging (X-ray, microCT)).
  • Standard molecular and biological techniques.
  • Cell culture, molecular biology, and signaling.
  • Design and execute experiments, collect and analyze data.
Technical Expertise
  • Highly skilled in soft wares like MS word, MS Excel, MS power point, Stat view, Photoshop, End note ect.
  • Highly skilled in Computer System Design.
Leadership and Mentoring
  • The ability to motivate, lead, and/or supervise the activities of others.
  • Effective communication (both written and oral) and problem solving skills.
Interpersonal Skills
  • Work as part of a team, frequently interacting with different people and working across projects.
Other interests
  • Reading books.
  • Photography.
 
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